engleski

Hyperlipidemic patients have an increased micropulmonary red cells mass

It is well known that pulmonary microcirculation rheology is partly affected by plasma levels of lipoproteins, but only a few data are available for humans. Therefore, in a sample of 30 healthy normolipidemic volunteers and 90 patients with varios types of primary hyperlipoproteinemia, the plasma levels of total cholesterol (Chol), low density cholesterol (LDL-chol), high denstiy cholesterol (HDL-Chol), triglycerides (Tg) and fibrinogen (Fib) were measured in conjunction with determinations of plasma viscosity (PV) and pulmonary capillary red cell mas (RCVc). Hyperlipidemic group consisted od 30 not treated patients with type IIa (Chol>7.8, Tg <2.3 mmol/L), 30 patients with type IV (Tg>4.6, Chol < 5.2 mmol/L), and 30 patients with type IIb (Tg>4.6, Chol > 7.8 mmol/L). RCVc was estimated from measurements of the vascular component of the single-breath diffusing lung capacity for carbon monoxide, using our own modification of the Roughton-Forster's method. RCVc was increased in hyperlipidemic patients up to 151%. By stepwise regression analysis, the variations in RCVc was almost completely accounted for (r2= 0.87) by variations in PV, Chol, Tg and the anthropometric confounding factors. The strangest association of RCVc was obtained with OV (r=0.79, b=217% P/m/Pa/S) followed by Chrol (r=0.71, b=5.73% P/mol-1). The proposed explanations for increased RCVc in hyperlipaemic patients include hypothesis of increased pulmonary microhematocrit, which agrees with an in vitro observed lipoprotein-dependent increase in erythrocyte aggregability.

hyperlipidaemia; micropulmonaly red cell mass; HDL cholesterol; LDL cholesterol

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