Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 818244

Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia


Lucijanić, Marko; Lasan-Trcic, Ružica: Kušec, Rajko; Pejša, Vlako; Štoos-Veić, Tajana; Jakšić, Ozren
Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia // Annals of hematology, 94 (2015), 9; 1617-1619 doi:10.1007/s00277-015-2428-6 (međunarodna recenzija, pismo, znanstveni)


CROSBI ID: 818244 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia

Autori
Lucijanić, Marko ; Lasan-Trcic, Ružica: Kušec, Rajko ; Pejša, Vlako ; Štoos-Veić, Tajana ; Jakšić, Ozren

Izvornik
Annals of hematology (0939-5555) 94 (2015), 9; 1617-1619

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
MDS ; del(12p) ; azacitidine
(MDS ; del (12p) ; azacitidine)

Sažetak
Treatment-related malignancies represent a lifelong problem reflecting underlying genome instability (obvious weak point at chromosome 17). Unique translocation (13 ; 17)(q12 ; q25) has not been described in MDS before and bears unknown prognostic significance (ZNF198, FLT3, BRCA2, and Septin from the rearranged chromosomal regions are possible candidate genes). Our heavily pretreated patient was successfully treated with azacitidine achieving prolonged remission.Therapy was well tolerated, and no reactivation of previous APL was observed. However, disease control was ultimately lost with the expansion of clone harboringdeletion 12p13 (locus of TEL/EFV6 gene) rendering azacitidine therapy ineffective. This association has not been described so far and implies potential molecular mechanisms worth investigating in further studies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava"

Profili:

Avatar Url Tajana Štoos-Veić (autor)

Avatar Url Vlatko Pejša (autor)

Avatar Url Ozren Jakšić (autor)

doi

Citiraj ovu publikaciju

Lucijanić, Marko; Lasan-Trcic, Ružica: Kušec, Rajko; Pejša, Vlako; Štoos-Veić, Tajana; Jakšić, Ozren
Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia // Annals of hematology, 94 (2015), 9; 1617-1619 doi:10.1007/s00277-015-2428-6 (međunarodna recenzija, pismo, znanstveni)
Lucijanić, M., Lasan-Trcic, Ružica: Kušec, Rajko, Pejša, V., Štoos-Veić, T. & Jakšić, O. (2015) Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia. Annals of hematology, 94 (9), 1617-1619 doi:10.1007/s00277-015-2428-6.
@article{article, year = {2015}, pages = {1617-1619}, DOI = {10.1007/s00277-015-2428-6}, keywords = {MDS, del(12p), azacitidine}, journal = {Annals of hematology}, doi = {10.1007/s00277-015-2428-6}, volume = {94}, number = {9}, issn = {0939-5555}, title = {Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia}, keyword = {MDS, del(12p), azacitidine} }
@article{article, year = {2015}, pages = {1617-1619}, DOI = {10.1007/s00277-015-2428-6}, keywords = {MDS, del (12p), azacitidine}, journal = {Annals of hematology}, doi = {10.1007/s00277-015-2428-6}, volume = {94}, number = {9}, issn = {0939-5555}, title = {Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13 ; 17)(q12 ; q25) after prior breast cancer and acute promyelocytic leukemia}, keyword = {MDS, del (12p), azacitidine} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font