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Biochemical and haematological parameters and their value in predicting preeclampsia (CROSBI ID 635469)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa

Štefanović, Mario ; Delić, Ratko Biochemical and haematological parameters and their value in predicting preeclampsia // Clinical chemistry and laboratory medicine. 2012. str. A186-x

Podaci o odgovornosti

Štefanović, Mario ; Delić, Ratko

engleski

Biochemical and haematological parameters and their value in predicting preeclampsia

Preeclampsia is a systemic syndrome that occurs in 5 to 8% of pregnancies and is a leading cause of maternal and neonatal morbidity and mortality. There are no clinically available tests that are well in selecting women who will develop preeclampsia. Purpose of the study was to combine standard biochemical and hematological markers at third trimester of pregnancy in assessing the risk of preeclampsia and to evaluate the use of additional generally available standard laboratory tests (in particular or in a group as a test panel), in prognosis of preeclampsia. This retrospective study was carried out on 113 patients with preeclampsia and a control group of 95 uncomplicated pregnancies. All subjects were in their 3-rd trimester of pregnancy and attended at Obstetric Department of the General Hospital Celje, Slovenia. Erythrocytes, leukocytes, thrombocytes, hemoglobin, hematocrit, AST, ALT, GGT, alkaline phosphatase, total bilirubin, urea, creatinine, uric acid, body mass index, parity, age, and blood type were evaluated to predict the occurrence of preeclampsia based on multivariate logistic regression model. ROC curve analysis pointed AUC of urate (0.856), creatinine (0.785) and urea (0.771) as the best preeclampsia predicting tests (p<0, 001). Logistic regression model with uric acid and urea combined as a test panel, correctly classified 79.6% patients. Inclusion of additional four parameters (thrombocytes, hematocrit, aspartate aminotransferase and leukocytes) in this model, correctly classifiy 83.8% patients with preeclampsia. Blood pressure and proteinuria were not included in the model, because they served as diagnostic criteria to diagnose preeclampsia. Our findings show that when combining several standard laboratory tests (thrombocytes, hematocrit, aspartate aminotransferase and leukocytes) in a logistic regression model, it is possible to distinguish 84% of the preeclampsia cases. If coupled with current criteria (a new onset of hypertension and proteinuria after 20 weeks of gestation in previously normotensive woman), this test panel should identify even more cases. After validation in an independent population, proposed test panel could be used as a tool to help identify women at risk for developing preeclampsia.

Biochemical; haematological; parameters; preeclampsia

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Podaci o prilogu

A186-x.

2012.

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objavljeno

Podaci o matičnoj publikaciji

Clinical chemistry and laboratory medicine

1437-4331

Podaci o skupu

4th Slovenian Congress of Clinical Chemistry

pozvano predavanje

28.09.2012-29.09.2012

Portorož, Slovenija

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost