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Pregled bibliografske jedinice broj: 817190

Serotonin transporter polymorphism (5-HTTLPR) in Croatian population


Culej, Jelena; Štefanović, Mario; Ćelap, Ivana; Nikolac, Nora; Karlović, Dalibor
Serotonin transporter polymorphism (5-HTTLPR) in Croatian population // Molecular biology reports, 42 (2015), 2; 553-558 doi:10.1007/s11033-014-3800-7 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 817190 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Serotonin transporter polymorphism (5-HTTLPR) in Croatian population

Autori
Culej, Jelena ; Štefanović, Mario ; Ćelap, Ivana ; Nikolac, Nora ; Karlović, Dalibor

Izvornik
Molecular biology reports (0301-4851) 42 (2015), 2; 553-558

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Serotonin transporter ; serotonin transporter polymorphism ; 5-HTTLPR ; population stratification

Sažetak
Serotonin transporter polymorphism (5-HTTLPR) is a well-studied polymorphism in psychiatric research. The function of serotonin transporter is to control neural stimulation and maintain homeostasis of serotonin in other cells like platelets and enterochromaffin cells. Considering serotonin function in human behavior, and the role of serotonin transporter, 5-HTTLPR has been associated with depression related disorders, anxiety related personality traits, and adverse response to psychotherapy. However, many studies failed to replicate the association of 5-HTTLPR polymorphism with mentioned disorders. The aim of our study was to assess genotype frequencies in Croatian physically and psychologically healthy population and compare our results with previously published data. Genotype distribution in our research was similar to previous studies on Caucasian population regardless of inclusion criteria. Genotype distribution was as follows: LL 38 % ; LS 45 % ; SS 17 % and allele frequencies for L and S allele were 61 and 39 %, respectively. Obtained results were in an agreement with the Hardy– Weinberg equilibrium. Comparing inclusion criteria from different studies, we noticed a difference in population selection from one study to another. Increased possibility for selection bias, population stratification and complexity of psychiatric disorders might present a source of possible errors in genetic association studies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Nora Nikolac (autor)

Avatar Url Mario Štefanović (autor)

Avatar Url Ivana Ćelap (autor)

Avatar Url Dalibor Karlović (autor)

Citiraj ovu publikaciju

Culej, Jelena; Štefanović, Mario; Ćelap, Ivana; Nikolac, Nora; Karlović, Dalibor
Serotonin transporter polymorphism (5-HTTLPR) in Croatian population // Molecular biology reports, 42 (2015), 2; 553-558 doi:10.1007/s11033-014-3800-7 (međunarodna recenzija, članak, znanstveni)
Culej, J., Štefanović, M., Ćelap, I., Nikolac, N. & Karlović, D. (2015) Serotonin transporter polymorphism (5-HTTLPR) in Croatian population. Molecular biology reports, 42 (2), 553-558 doi:10.1007/s11033-014-3800-7.
@article{article, year = {2015}, pages = {553-558}, DOI = {10.1007/s11033-014-3800-7}, keywords = {Serotonin transporter, serotonin transporter polymorphism, 5-HTTLPR, population stratification}, journal = {Molecular biology reports}, doi = {10.1007/s11033-014-3800-7}, volume = {42}, number = {2}, issn = {0301-4851}, title = {Serotonin transporter polymorphism (5-HTTLPR) in Croatian population}, keyword = {Serotonin transporter, serotonin transporter polymorphism, 5-HTTLPR, population stratification} }
@article{article, year = {2015}, pages = {553-558}, DOI = {10.1007/s11033-014-3800-7}, keywords = {Serotonin transporter, serotonin transporter polymorphism, 5-HTTLPR, population stratification}, journal = {Molecular biology reports}, doi = {10.1007/s11033-014-3800-7}, volume = {42}, number = {2}, issn = {0301-4851}, title = {Serotonin transporter polymorphism (5-HTTLPR) in Croatian population}, keyword = {Serotonin transporter, serotonin transporter polymorphism, 5-HTTLPR, population stratification} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE
  • Pubmed


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