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Pregled bibliografske jedinice broj: 816247

Hyperbaric environment upregulates CD15s expression on leukocytes, downregulates CD77 expression on renal cells and upregulates CD34 expression on pulmonary and cardiac cells in rat


Đevenica, Danka; Markotić, Anita; Režić-Mužinić, Nikolina; Jelaska, Igor; Zemunik, Tatijana; Delić, Hrvoje; Čikeš Čulić, Vedrana
Hyperbaric environment upregulates CD15s expression on leukocytes, downregulates CD77 expression on renal cells and upregulates CD34 expression on pulmonary and cardiac cells in rat // Iranian Journal of Basic Medical Sciences, 19 (2016), 8; 821-828 doi:10.22038/ijbms.2016.7462 (međunarodna recenzija, članak, znanstveni)


Naslov
Hyperbaric environment upregulates CD15s expression on leukocytes, downregulates CD77 expression on renal cells and upregulates CD34 expression on pulmonary and cardiac cells in rat

Autori
Đevenica, Danka ; Markotić, Anita ; Režić-Mužinić, Nikolina ; Jelaska, Igor ; Zemunik, Tatijana ; Delić, Hrvoje ; Čikeš Čulić, Vedrana

Izvornik
Iranian Journal of Basic Medical Sciences (2008-3866) 19 (2016), 8; 821-828

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD77 (globotriaosylceramide) ; CD15s (sialyl Lexis X antigen) ; hyperbaric environment ; CD34 antigen

Sažetak
The aim of this study was to estimate effects of hyperbaric (HB) treatment by determination of CD15s and CD11b leukocyte proinflammatory markers expression. In addition, this study describes changes in CD77 and CD34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. Expression of CD11b and CD15s on leukocytes, as well as CD77 and CD34 expression on endothelial cells in cell suspensions of renal, pulmonary and cardiac tissue in rats after hyperbaric treatment and in control rats were determined by flow cytometry. Hyperbaric treatment significantly increased percentage of leukocytes expressing CD15s+CD11b- (from 1.71 ±1.11 to 23.42 ±2.85, P < 0.05). Hyperbaric treatment significantly decreased sum percentage of CD77+CD34- and CD77+CD34+ renal cells (from 16.35±5.5 to 4.48 ±1.28, P < 0.05). Hyperbaric treatment significantly increased percentage of CD34+ pulmonary cells (from 3.27±2.01 to 11.92 ±6.22, P < 0.05). Our study is the first reporting the hyperbaric environment influence on CD34+ heart cells in rats. The current findings of increased percentage of leukocytes expressing endothelial selectin ligand CD15s after hyperbaric treatment, point its role in endothelial damage prevention. We found out a significantly increase in percentage of CD34+ cardiac cells as well as CD34+ pulmonary cells in rats after HB treatment which could be a part of repair mechanism of injured endothelium caused by hyperoxia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-2160133-0066 - Patobiokemija glikosfingolipidnih antigena (Anita Markotić, )

Ustanove
Medicinski fakultet, Split,
Kineziološki fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE
  • TR, PubMed Central, Scopus


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