engleski

NONALCOHOLIC FATTY LIVER DISEASE DETECTED BY TRANSIENT ELASTOGRAPHY IN THE PATIENTS WITH INFLAMMATORY BOWEL DISEASE – A PILOT STUDY

BACKGROUND/AIM: Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and is strongly related to all metabolic syndrome components. Its prevalence in patients with inflammatory bowel disease (IBD) is less known. Thus, our aim was to investigate the incidence of NAFLD in patients with IBD. METHODS: In this cross-sectional study we have analyzed 19 patients with IBD (10 UC and 9 CD). The controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) were used to detect and quantify liver steatosis and fibrosis with the help of transient elastography (TE) (FibroScan®, Echosense SA, Paris, France). NAFLD was defined by the presence of steatosis and CAP values ≥238 dB/m, regardless of the presence or absence of any stage of fibrosis and exclusion of other secondary causes of chronic liver disease. RESULTS: The mean age of our patients was 46.5±16.4 years. There were 10 men and nine females. The mean values of CAP and LSM were 234.4±55.8 db/m and 5.7±2.5 kPa, respectively. Of 19 analyzed patients 10 had NAFLD (CAP≥238 db/m). There was a significant positive correlation between CAP measurements and waist circumference (r=0.927 ; p=0.0003) as well as between CAP measurements and patients body weight (r=0.702 ; p=0.003). On the other hand we did not found significant correlation among investigated liver tests (i.e. alanin-aminotransferase, aspartat-aminotransferase and gamma-glutamil transferase) and CAP measurements. CONCLUSION: According to our pilot study, it seems that IBD patients have a high prevalence of TE defined NAFLD. But further studies that will investigate the truly prevalence of NAFLD in IBD patients as well as studies that will give us answer what factors are related to NAFLD in IBD patients are urgently needed.

Nonalcoholic fatty liver disease; inflammatory bowel disease

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