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Pregled bibliografske jedinice broj: 815643

The missing link - likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy


Vuković, Igor; Božić, Joško; Markotić, Anita; Ljubičić, Srećko; Tičinović Kurir, Tina
The missing link - likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy // Kidney & blood pressure research, 40 (2015), 3; 306-314 doi:10.1159/000368506 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
The missing link - likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy

Autori
Vuković, Igor ; Božić, Joško ; Markotić, Anita ; Ljubičić, Srećko ; Tičinović Kurir, Tina

Izvornik
Kidney & blood pressure research (1420-4096) 40 (2015), 3; 306-314

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Ganglioside ; GM3 ; diabetic nephropathy ; lipid rafts

Sažetak
Despite scientific advances, diabetic nephropathy remains both a therapeutical challenge, and one of the major diabetic complications. Chemical structure of gangliosides, the most complex of glycosphingolipids, is characterised by one or more sialic acids and carbohydrate groups linked to a ceramide structure. Their potential pathogenetic role in a number of disorders linked to diabetes mellitus has recently been conjectured, due to evidence of their negative modulation of the insulin-mediated signaling and general effects on key cell functions like proliferation, differentiation, apoptosis, cellular signaling and adhesion. Elevated levels of advanced glycation products (AGE) usually found in diabetic conditions seem to be responsible for increased concentration of a-series gangliosides in tissues, most notably GM3. GM3 was shown to compromise the renal pericyte and mesangial cell regeneration via the inactivation of VEGF receptor and the receptor-associated Akt signaling pathway. Likewise, the lipid raft theory opened a new research area for GM3 influence, since in the glycosynapse model glycosphingolipids have a key cell-to-cell communication unit with modulating capabilities on signaling receptors. The goal of this review is to provide insight into currently available theories on proposed mechanisms that mark the GM3 as a pathophysiological mediator in the development of diabetic nephropathy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-2160133-0066 - Patobiokemija glikosfingolipidnih antigena (Anita Markotić, )

Ustanove
KBC Split,
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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