engleski

Synthesis, acute toxicity and protective action of some new oximes in experimental soman poisoning. Imidazole derivatives. VI.

A series of (bis-imidazolium and imidazolium- pyridinium) oximes, linked together with alkane, ether and diether chains, and with methyl, benzyl, phenyl and 4-fluorophenyl substituents at position 3 of the imidazole ring, were prepared. All compounds were characterized by elemental analysis, IR and proton NMR-spectroscopy. Their acute toxicity (LD50) determined in male mice varied from 0.0008 to 0.124 mmol/kg. Oximes 2C and 2E, given together with atropine sulfate (10 mg/kg), provided a 100% protection against 1.8 x LD50 soman and oxime 2B against 2.2 x LD50 soman.

Imidazolium oximes ; synthesis ; toxicity ; protection ; soman poisoning

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