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Pregled bibliografske jedinice broj: 814704

Fusion leads to effective segregation of damage during cell division: An analytical treatment


Lade, Steven J.; Coelho, Miguel; Tolić, Iva Marija; Gross, Thilo
Fusion leads to effective segregation of damage during cell division: An analytical treatment // Journal of theoretical biology, 378 (2015), 47-55 doi:10.1016/j.jtbi.2015.04.022 (međunarodna recenzija, članak, znanstveni)


Naslov
Fusion leads to effective segregation of damage during cell division: An analytical treatment

Autori
Lade, Steven J. ; Coelho, Miguel ; Tolić, Iva Marija ; Gross, Thilo

Izvornik
Journal of theoretical biology (0022-5193) 378 (2015); 47-55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Aggregation ; Damage partition ; Van Kampen expansion ; Directed transport

Sažetak
High levels of cellular damage are associated with impairment of cellular function and cell death. Partitioning the damage into a fraction of cells in the population improves population fitness and survival. We have previously shown that protein aggregates, resulting from misfolded, damaged proteins, fuse with each other leading to damage partitioning during cell division. Here, using an analytical treatment of aggregate fusion in dividing cells we present analytical expressions for two measures of damage partition: aggregate mass partition asymmetry between two dividing cells and standard deviation of total aggregate mass across the population. The scaling laws obtained demonstrate how damage partition may generally depend on characteristics of the cellular processes, facilitating better understanding of damage segregation in biological cells.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Iva Marija Tolić, (260543)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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