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Pregled bibliografske jedinice broj: 814263

Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens


Oguić, Romano; Mozetič, Vladimir; Cini Tešar, Eleonora; Fučkar Čupić, Dora; Mustać, Elvira; Đorđević, Gordana
Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens // Pathology Research International, 2014 (2014), 262195, 8 doi:10.1155/2014/262195 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 814263 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens

Autori
Oguić, Romano ; Mozetič, Vladimir ; Cini Tešar, Eleonora ; Fučkar Čupić, Dora ; Mustać, Elvira ; Đorđević, Gordana

Izvornik
Pathology Research International (2090-8091) 2014 (2014); 262195, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Prostate cancer ; The expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) ; Positive surgical margin

Sažetak
The aim of this study was to evaluate the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in prostate cancer in the main tumor mass and tumor cells at the positive margin as well as the influence of these biomarkers on the biochemical recurrence of the disease in prostatectomy patients. Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters. Tumors with positive surgical margins showed significantly higher overall expression of MMP-9 versus tumors with negative resection margins (P = 0.0121). MMP-9 expression was significantly elevated in tumors from patients who had biochemical recurrence (P = 0.0207). In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence (P = 0.0065). Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29 ; P = 0.0052). Expression of MMP-2 in tumor cells was significantly higher at the positive margins than in the main tumor mass (P = 0.0301). The present results highlight the potential value of MMP-2 and MMP-9 expression for predicting the behavior of prostate tumors after prostatectomy with both positive and negative surgical margins.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620095-0077 - Molekularni mehanizmi tumorske progresije i metastaziranja raka dojke i prostate (Mustać, Elvira, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju:

Oguić, Romano; Mozetič, Vladimir; Cini Tešar, Eleonora; Fučkar Čupić, Dora; Mustać, Elvira; Đorđević, Gordana
Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens // Pathology Research International, 2014 (2014), 262195, 8 doi:10.1155/2014/262195 (međunarodna recenzija, članak, znanstveni)
Oguić, R., Mozetič, V., Cini Tešar, E., Fučkar Čupić, D., Mustać, E. & Đorđević, G. (2014) Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens. Pathology Research International, 2014, 262195, 8 doi:10.1155/2014/262195.
@article{article, author = {Ogui\'{c}, Romano and Mozeti\v{c}, Vladimir and Cini Te\v{s}ar, Eleonora and Fu\v{c}kar \v{C}upi\'{c}, Dora and Musta\'{c}, Elvira and \DJor\djevi\'{c}, Gordana}, year = {2014}, pages = {8}, DOI = {10.1155/2014/262195}, chapter = {262195}, keywords = {Prostate cancer, The expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9), Positive surgical margin}, journal = {Pathology Research International}, doi = {10.1155/2014/262195}, volume = {2014}, issn = {2090-8091}, title = {Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens}, keyword = {Prostate cancer, The expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9), Positive surgical margin}, chapternumber = {262195} }
@article{article, author = {Ogui\'{c}, Romano and Mozeti\v{c}, Vladimir and Cini Te\v{s}ar, Eleonora and Fu\v{c}kar \v{C}upi\'{c}, Dora and Musta\'{c}, Elvira and \DJor\djevi\'{c}, Gordana}, year = {2014}, pages = {8}, DOI = {10.1155/2014/262195}, chapter = {262195}, keywords = {Prostate cancer, The expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9), Positive surgical margin}, journal = {Pathology Research International}, doi = {10.1155/2014/262195}, volume = {2014}, issn = {2090-8091}, title = {Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens}, keyword = {Prostate cancer, The expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9), Positive surgical margin}, chapternumber = {262195} }

Časopis indeksira:


  • Scopus
  • MEDLINE


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