Napredna pretraga

Pregled bibliografske jedinice broj: 814237

MEĐU-LABORATORIJSKA PODUDARNOST HER-2 POZITIVNIH KARCINOMA DOJKE


Jonjić, Nives; Mustać, Elvira; Tomić, Snježana; Razumović Jakić, Jasminka; Šarčević, Božena; Blažičević, Valerija; Labinac Peteh, Loredana; Švagelj, Dražen; Kopjar, Andrina; Šikić Lisica, Nataša et al.
MEĐU-LABORATORIJSKA PODUDARNOST HER-2 POZITIVNIH KARCINOMA DOJKE // Acta clinica Croatica, 54 (2015), 4; 479-485 (recenziran, članak, stručni)


Naslov
MEĐU-LABORATORIJSKA PODUDARNOST HER-2 POZITIVNIH KARCINOMA DOJKE
(Interlaboratory Concordance in HER-2 Positive Breast Cancer)

Autori
Jonjić, Nives ; Mustać, Elvira ; Tomić, Snježana ; Razumović Jakić, Jasminka ; Šarčević, Božena ; Blažičević, Valerija ; Labinac Peteh, Loredana ; Švagelj, Dražen ; Kopjar, Andrina ; Šikić Lisica, Nataša ; Vrbičić, Branka ; Borić, Igor

Izvornik
Acta clinica Croatica (1333-9451) 54 (2015), 4; 479-485

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Rak dojke; HER-2; Imunohistokemija; In situ hibridizacija; fluorescentna; Kontrola kvalitete
(Breast cancer; HER-2; Immunohistochemistry; In situ hybridization; Quality control)

Sažetak
Accurate assessment of HER-2 status is essential for identifying patients who will benefit from HER-2 targeted therapy. The aim of the present study was to show results on the concordance between local and central laboratory testing results in HER-2 positive breast cancer patients. In cases with discordant findings, the immunohistochemical (IHC) and/or in situ hybridization (FISH/SISH) analysis was performed in central laboratories. A total of 104 out of 143 (72.72%) breast carcinomas cases were HER-2 positive (score 3+), while nearly 14% of tumors (20/43) showed weak (score 2+) and 12% (19/143) negative IHC staining (score 0 and 1+). After repeated IHC and ISH, 88% (126/143) were classified as HER-2 positive and 12% (17/143) as HER-2 negative cases. The results obtained are in agreement with many studies that confirmed similar discordance in HER-2 testing by IHC and/or FISH between local and central laboratory. Thus, our findings as well as of other studies support the importance of regular quality assessment of the staining procedures performed and consistency of interpretation of HER-2 test results.

Izvorni jezik
Engleski

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE