The role of dehydroepiandrosterone (DHEA) in schizophrenia (CROSBI ID 227857)
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Vuksan-Ćusa, Bjanka ; Šagud, Marina ; Radoš, Iva
engleski
The role of dehydroepiandrosterone (DHEA) in schizophrenia
Neurosteroid dehydropiandrosterone (DHEA) and its sulphate (DHEAS) are reported to have modulatory effects on neuronal excitabillity and synaptic plasticity. DHEA and DHEAS are synthesized in central and peripheral nervous system from cholesterol or steroidal precursors imported from peripheral sources. There is accumulating evidence that alterations in DHEA(S) levels may be involved in the pathophysiology of schizophrenia. The possible effects of DHEA(S) as augmentation therapy in schizophrenia, related to psychological and somatic aspects of this disease, are discussed.
schizophrenia – dehydroepiandrosterone – DHEA – DHEAS - augmentation therapy
PMID: 26938818 PubMed.
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