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Pregled bibliografske jedinice broj: 814041

Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma


Kafka, Anja; Bačić, Mateja; Morić, Marina: Skoko, Josip, Pećina-Šlaus, Nives
Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma // GlowBrain Workshop "Visualization of molecular markers in the brain"
Zagreb, Hrvatska, 2015. str. 53-53 (poster, domaća recenzija, sažetak, ostalo)


CROSBI ID: 814041 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma

Autori
Kafka, Anja ; Bačić, Mateja ; Morić, Marina: Skoko, Josip, Pećina-Šlaus, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
GlowBrain Workshop "Visualization of molecular markers in the brain" / - , 2015, 53-53

Skup
GlowBrain Workshop

Mjesto i datum
Zagreb, Hrvatska, 29-31.01.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
glioblastoma ; DVL1 ; DVL3 ; wnt signaling

Sažetak
Molecular landscape of human brain tumors still needs elucidation. Glioblastoma are the most aggressive and the most invasive tumors of central nervous system. There are specific signalling pathways involved in disease development, among which is Wnt pathway. Dishevelled (DVL) is cytoplasmatic phosphoprotein, who comes first in downstream cascade from receptor Frizzled (Fz). When the signalization mediated by DVL is disrupted, it results in tumor development and progression. In the present study we aim to investigate the incompletely understood role of Dishevelled (Dvl) gene family, which is considered to be the central hub of wnt signaling Genetic changes of DVL1 and DVL3 were tested by PCR/loss of heterozygosity (LOH) method using D1S468 microsatellite marker for DVL1 gene and D36S1262 for DVL3 gene. Protein expressions and localizations were analyzed by immunohistochemistry.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-6625 - Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji (WNT4EMT) (Pećina-Šlaus, Nives, HRZZ - 2013-11) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Anja Kafka (autor)


Citiraj ovu publikaciju:

Kafka, Anja; Bačić, Mateja; Morić, Marina: Skoko, Josip, Pećina-Šlaus, Nives
Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma // GlowBrain Workshop "Visualization of molecular markers in the brain"
Zagreb, Hrvatska, 2015. str. 53-53 (poster, domaća recenzija, sažetak, ostalo)
Kafka, A., Bačić, M. & Morić, Marina: Skoko, Josip, Pećina-Šlaus, Nives (2015) Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma. U: GlowBrain Workshop "Visualization of molecular markers in the brain".
@article{article, year = {2015}, pages = {53-53}, keywords = {glioblastoma, DVL1, DVL3, wnt signaling}, title = {Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma}, keyword = {glioblastoma, DVL1, DVL3, wnt signaling}, publisherplace = {Zagreb, Hrvatska} }
@article{article, year = {2015}, pages = {53-53}, keywords = {glioblastoma, DVL1, DVL3, wnt signaling}, title = {Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma}, keyword = {glioblastoma, DVL1, DVL3, wnt signaling}, publisherplace = {Zagreb, Hrvatska} }




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