engleski

Adiponectin, resistin and myostatin in overweight dogs

Overweight is a very common problem of humans and dogs. Today it is widely accepted that adipose tissue has the endocrine function and ability to synthesize many substances, including adipokines. They are now in the focus of attention as potential biomarkers of complications associated with obesity. The objective of this study was to evaluate the influence of overweight on adipokines and myokines plasma concentrations in dogs and compare them to inflammatory and fibrinolytic markers. ADN in overweight dogs was significantly inversely related to overweight, as in humans, primates and rodents. Since ADN has anti-inflammatory and anti-atherogenic properties, hypoadiponectinemia may represent a risk for the development of proinflammatory state and cardiovascular complications in overweight dogs. The increase of adipose tissue in dogs results in increased concentrations of MYO in circulation. This is consistent with human obesity, where is also found increase in circulating MYO (1). The role of MYO in the development of obesity is not fully understood. MYO can directly slow the growth and differentiation of adipocytes, however, inhibition of myostatin signal can significantly reduce the development of obesity (2). Recent data of Shan et al. (3) suggest that reducing of MYO signaling represents a therapeutic tools to treat obesity, transforming white adipose tissue to brown. RES concentration in overweight dogs was similar to those obtained in lean group of dogs. This could be due the site of production in dogs - RES is primary secreted by immune and epithelial cells. Our study suggests that circulating RES in canine obesity is more strongly associated with inflammatory and fibrinolytic markers than with obesity, which is consistent with recent studies in humans. Since many influences of overweight on the health of dogs are similar to those in humans, significant progress can be achieved in the prevention and treatment of overweight in dogs. Vice versa, dogs can serve as easily accessible model to investigate the impact of obesity on some adypokine secretion, inflammatory and coagulation processes.

adiponectin; resistin; myostatin; overweight; dog

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