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Pregled bibliografske jedinice broj: 813542

EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival


Katunarić, Miljenko; Jurišić, Davor; Petković, Marija; Grahovac, Maja; Grahovac, Blaženka; Zamolo, Gordana
EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival // Melanoma research, 24 (2014), 6; 584-591 doi:10.1097/CMR.0000000000000123 (međunarodna recenzija, članak, znanstveni)


Naslov
EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival

Autori
Katunarić, Miljenko ; Jurišić, Davor ; Petković, Marija ; Grahovac, Maja ; Grahovac, Blaženka ; Zamolo, Gordana

Izvornik
Melanoma research (0960-8931) 24 (2014), 6; 584-591

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Melanoma ; EGFR ; ulceration

Sažetak
Considering that nodular melanoma (NM) has the potential to show an early distant metastasis, there is an urgent need for the discovery and evaluation of new diagnostic and prognostic biomarkers. We aimed to investigate the protein expression of membrane and nuclear epidermal growth factor receptor (EGFR), cyclin D1, and the corresponding gene status in NM samples and correlate the results obtained with clinicopathological parameters and overall survival of patients. Immunohistochemical and fluorescence in-situ hybridization analyses were carried out on tissue microarrays constructed from 110 NM samples, 30 compound nevi, and 38 dysplastic nevi. NM samples showed 24% strong cyclin D1 and 37% strong Ki67 protein expression compared with 3 and 0% strong cyclin D1 and Ki67 expression in the control group. Membrane EGFR expression was detected in 50% of NM cases, whereas EGFR gene amplification was detected in only 4% of NM cases. Multiple NM samples presented simultaneous membrane and nuclear EGFR expression. We found a negative correlation between tumor thickness and membrane EGFR expression. It was also observed that membrane EGFR 3+ NM samples presented ulceration significantly more often than membrane EGFR-negative (0) NM samples. In univariate analysis, carried out on 44 patients with follow-up data, both nuclear and membrane EGFR overexpression showed a correlation with a shorter overall survival. Nuclear EGFR (++, +++) showed 3.06 and membrane EGFR (2+, 3+) showed 2.76 higher risk of mortality compared with patients with low and negative nuclear and membrane EGFR expression (P<0.05).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-3545 - Telomerazna aktivnost i imunofenotipske karakteristike limfocita u melanomu kože (Gordana Zamolo, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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