engleski

Ribosomal Biogenesis Stress and p53 Activation

Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. I will discuss when, how and why p53 is activated upon ribosome biogenesis stress, and how perturbation of this critical regulatory interplay may impact disease.

ribosomal biogenesis; p53

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