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Ribosomal Biogenesis Stress and p53 Activation (CROSBI ID 634746)

Neobjavljeno sudjelovanje sa skupa | neobjavljeni prilog sa skupa

Volarević, Siniša Ribosomal Biogenesis Stress and p53 Activation // International two-day workshop "RNA Biology meets Sleep and Circadian Rhythms" Gloucester, Ujedinjeno Kraljevstvo, 26.06.2014-27.06.2014

Podaci o odgovornosti

Volarević, Siniša

engleski

Ribosomal Biogenesis Stress and p53 Activation

Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53-activating checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2. I will discuss when, how and why p53 is activated upon ribosome biogenesis stress, and how perturbation of this critical regulatory interplay may impact disease.

ribosomal biogenesis; p53

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Podaci o prilogu

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Podaci o skupu

International two-day workshop "RNA Biology meets Sleep and Circadian Rhythms"

pozvano predavanje

26.06.2014-27.06.2014

Gloucester, Ujedinjeno Kraljevstvo

Povezanost rada

Temeljne medicinske znanosti