Ribosomal Biogenesis Stress and p53 Activation (CROSBI ID 634746)
Neobjavljeno sudjelovanje sa skupa | neobjavljeni prilog sa skupa
Podaci o odgovornosti
Volarević, Siniša
engleski
Ribosomal Biogenesis Stress and p53 Activation
Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53-activating checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2. I will discuss when, how and why p53 is activated upon ribosome biogenesis stress, and how perturbation of this critical regulatory interplay may impact disease.
ribosomal biogenesis; p53
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
nije evidentirano
nije evidentirano
Podaci o skupu
International two-day workshop "RNA Biology meets Sleep and Circadian Rhythms"
pozvano predavanje
26.06.2014-27.06.2014
Gloucester, Ujedinjeno Kraljevstvo