Ribosomal proteins and p53 activation (CROSBI ID 634745)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Volarević, Siniša
engleski
Ribosomal proteins and p53 activation
Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53-activating checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2. Our research interests focus on understanding the molecular basis of this checkpoint response and determining its role in pathogenesis of various diseases.
p53; ribosomal proteins
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Podaci o prilogu
25-25.
2014.
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objavljeno
Podaci o matičnoj publikaciji
INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses
Atena:
Podaci o skupu
INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses
pozvano predavanje
23.04.2014-25.04.2014
Atena, Grčka