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Ribosomal proteins and p53 activation (CROSBI ID 634745)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Volarević, Siniša Ribosomal proteins and p53 activation // INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses. Atena, 2014. str. 25-25

Podaci o odgovornosti

Volarević, Siniša

engleski

Ribosomal proteins and p53 activation

Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53-activating checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of specific ribosomal components with the p53 negative regulator, Mdm2. Our research interests focus on understanding the molecular basis of this checkpoint response and determining its role in pathogenesis of various diseases.

p53; ribosomal proteins

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Podaci o prilogu

25-25.

2014.

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objavljeno

Podaci o matičnoj publikaciji

INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses

Atena:

Podaci o skupu

INsPiRE International Workshop on: Oncogenic Pathways and Anti-tumor Responses

pozvano predavanje

23.04.2014-25.04.2014

Atena, Grčka

Povezanost rada

Temeljne medicinske znanosti