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Pregled bibliografske jedinice broj: 813362

Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC


Ahel, Juraj; Dordevic, Gordana; Markic, Dean; Mozetic Vladimir; Spanjol, Josip; Grahovac, Blazenka; Stifter, Sanja
Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC // Medical Hypotheses, 85 (2015), 2; 183-185 doi:10.1016/j.mehy.2015.04.033. (podatak o recenziji nije dostupan, članak, ostalo)


Naslov
Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC

Autori
Ahel, Juraj ; Dordevic, Gordana ; Markic, Dean ; Mozetic Vladimir ; Spanjol, Josip ; Grahovac, Blazenka ; Stifter, Sanja

Izvornik
Medical Hypotheses (0306-9877) 85 (2015), 2; 183-185

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Renal cell carcinoma (RCC) ; EGFR expression ; tumor differentiation

Sažetak
Renal cell carcinoma (RCC) is the most common solid kidney tumor representing 2-3% of all cancers, with the highest frequency occurring in Western countries. There was a worldwide and European annual increase in incidence of approximately 2% although incidence has been stabilized in last few years. One third of the patients already have metastases in the time of the diagnosis with poor prognosis because RCC are radio and chemoresistant. The prognostic value of EGFR over-expression in RCC is a controversial issue that could be explained by different histological types of study tumors and non-standardized criteria for evaluation of expression. Recent evidences points to a new mode of EGFR signaling pathway in which activated EGFR undergoes nuclear translocalization and then, as transcription factor, mediates gene expression and other cellular events required for highly proliferating activities. According to our observations, the membranous expression of EGFR associates with high nuclear grade and poor differentiated tumors. On the other hand, nuclear EGFR expression was high in low nuclear graded and well differentiated tumors with good prognosis. We hypothesize that this mode of EGFR signaling characterizes still controlled proliferation retained in well differentiated RCC with Furhman nuclear grade I or II.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • METADEX: Metals Science
  • Index Medicus
  • PubMed
  • Elsevier BIOBASE/Current Awareness in Biological Sciences


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