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Pregled bibliografske jedinice broj: 813361

Rapid fatal acute peripheral T-cell lymphoma associated with IgG plasma cell leukemia and IgA hypergammaglobulinemia : case report


Jonjić, Nives; Seili-Bekafigo, Irena; Fučkar- Čupić, Dora; Lučin, Ksenija; Duletić- Načinović, Antica; Valković, Toni
Rapid fatal acute peripheral T-cell lymphoma associated with IgG plasma cell leukemia and IgA hypergammaglobulinemia : case report // Applied immunohistochemistry & molecular morphology, 24 (2016), 10; e89-e93 doi:10.1097/PAI.0000000000000361 (podatak o recenziji nije dostupan, članak, stručni)


Naslov
Rapid fatal acute peripheral T-cell lymphoma associated with IgG plasma cell leukemia and IgA hypergammaglobulinemia : case report

Autori
Jonjić, Nives ; Seili-Bekafigo, Irena ; Fučkar- Čupić, Dora ; Lučin, Ksenija ; Duletić- Načinović, Antica ; Valković, Toni

Izvornik
Applied immunohistochemistry & molecular morphology (1062-3345) 24 (2016), 10; E89-e93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Leukemia ; plasma cell ; Lymphoma ; T cell ; Hypergammaglobulinemia

Sažetak
Simultaneous occurrence of T-cell and B-cell neoplasms is rare and etiologic relationships between these two malignancies are poorly understood. We describe a case of 66-year-old woman who was admitted to the hospital because of fever, hemoptysis, lymphadenopathy, and skin rash. Enlarged lymph nodes in the axillary, pectoral, paratracheal and periportal regions, as well as slight hepato- and splenomegaly were confirmed. Peripheral blood smear revealed rouleaux formation and numerous circulating plasma cells, with plasmacytoid lymphocytes. Immunofixation- electrophoresis detected a monoclonal band defined as IgG-lambda light chains with broad band polyclonal IgA. The patient died from abrupt splenic rupture before diagnostic work-up was finished. Postmortem examination revealed infiltration of atypical lymphoid cells exhibiting high proliferative activity admixed with typical and atypical plasma cells in several organs. Thus plasma cell leukemia (IgG-lambda) as a rare and aggressive variant of plasma cell myeloma in present case was associated with aggressive peripheral T cell lymphoma and polyclonal (IgA) plasmacytosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
061-0620095-0078
061-0620095-0079
061-0620095-0082
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Antica Duletić-Načinović, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Scopus
  • MEDLINE


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