engleski

Alteration in coagulation profile in naturally overweight and obese dogs

Overweight and obesity are a major health problem today, both in humans and in dogs. It is estimated that more than 40% of dogs that people keep as pets are overweight. Proliferated adipose tissue may release numerous mediators that induce a chronic inflammatory state, which is closely connected with haemostatic disturbances. Our findings indicate the presence of chronic inflammatory state in canine obesity, characterised by increase of proinflammatory citokine IL-6. As a major mediator of acute phase protein synthesis, IL-6 could contribute to upregulation of FIB as well as Y FIB, which lead to prothrombotic state. Rein-Smith et al. (3) showed that IL-6 cause 3.6 fold increase γA mRNA and 8.3-fold increase in γ' mRNA. Since elevated plasma FIB and especially the Y FIB promotes thrombosis, disruption of IL-6 signaling may be a potential target for minimalizing the influence of inflammatory state to haemostatic disturbances and thrombotic events. Excess of weight in humans may influence the function of coagulation cascade through a transcription factor which regulates the synthesis of FVII and FIX in liver (4). The obtained results in our study confirms the mechanisms of simultaneous activities of plasma coagulation factors, predisposing overweight and obese dogs to hypercoagulability.

coagulation; overweight; dogs

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