Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 813334

Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma


Valković, Toni; Babarović, Emina; Lučin, Ksenija; Štifter, Sanja; Aralica, Merica; Seili-Bekafigo, Irena; Duletić-Načinović, Antica; Jonjić, Nives
Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma // BioMed Research International, / (2016), 7870590-1 doi:10.1155/2016/7870590 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 813334 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma

Autori
Valković, Toni ; Babarović, Emina ; Lučin, Ksenija ; Štifter, Sanja ; Aralica, Merica ; Seili-Bekafigo, Irena ; Duletić-Načinović, Antica ; Jonjić, Nives

Izvornik
BioMed Research International (2314-6141) (2016); 7870590-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MCP-1 ; angiogenesis ; multiple myeloma

Sažetak
The aim of this pilot study was to determine the plasma levels of monocyte chemotactic protein-1 (MCP-1) and possible associations with angiogenesis and the main clinical features of untreated patients with multiple myeloma (MM). ELISA was used to determine plasma MCP-1 levels in 45 newly diagnosed MM patients and 24 healthy controls. The blood vessels were highlighted by immunohistochemical staining, and computer- assisted image analysis was used for more objective and accurate determination of two parameters of angiogenesis: microvessel density (MVD) and total vascular area (TVA). The plasma levels of MCP-1 were compared to these parameters and the presence of anemia, renal dysfunction, and bone lesions. A significant positive correlation was found between plasma MCP-1 concentrations and TVA (p = 0.02). The MCP-1 levels were significantly higher in MM patients with evident bone lesions (p = 0.01), renal dysfunction (p = 0.02), or anemia (p = 0.04). Therefore, our preliminary results found a positive association between plasma MCP-1 levels, angiogenesis (expressed as TVA), and clinical features in patients with MM. However, additional prospective studies with a respectable number of patients should be performed to authenticate these results and establish MCP-1 as a possible target of active treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Lučin, Ksenija, MZOS)
062-0620095-0079 - Uloga kemokina u patogenezi multiplog mijeloma (Valković, Toni, MZOS)
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS)
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Duletić-Načinović, Antica, MZOS)

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Fakultet zdravstvenih studija u Rijeci

Citiraj ovu publikaciju

Valković, Toni; Babarović, Emina; Lučin, Ksenija; Štifter, Sanja; Aralica, Merica; Seili-Bekafigo, Irena; Duletić-Načinović, Antica; Jonjić, Nives
Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma // BioMed Research International, / (2016), 7870590-1 doi:10.1155/2016/7870590 (međunarodna recenzija, članak, znanstveni)
Valković, T., Babarović, E., Lučin, K., Štifter, S., Aralica, M., Seili-Bekafigo, I., Duletić-Načinović, A. & Jonjić, N. (2016) Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International, /, 7870590-1 doi:10.1155/2016/7870590.
@article{article, year = {2016}, pages = {7870590-1-7870590-7}, DOI = {10.1155/2016/7870590}, keywords = {MCP-1, angiogenesis, multiple myeloma}, journal = {BioMed Research International}, doi = {10.1155/2016/7870590}, volume = {/}, issn = {2314-6141}, title = {Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma}, keyword = {MCP-1, angiogenesis, multiple myeloma} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font