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Pregled bibliografske jedinice broj: 812966

EGFR activated cell mobility–A link to melanoma ulceration


Katunarić, Miljenko; Zamolo, Gordana; Jonjić, Nives
EGFR activated cell mobility–A link to melanoma ulceration // Medical hypotheses, 85 (2015), 4; 498-499 doi:10.1016/j.mehy.2015.07.007 (međunarodna recenzija, članak, znanstveni)


Naslov
EGFR activated cell mobility–A link to melanoma ulceration

Autori
Katunarić, Miljenko ; Zamolo, Gordana ; Jonjić, Nives

Izvornik
Medical hypotheses (0306-9877) 85 (2015), 4; 498-499

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Melanoma ulceration ; EGFR activity ; cell mobility

Sažetak
Melanoma ulceration is the third most powerful survival predictor in the analysis for the currently valid 2010 AJCC melanoma staging system. However, there is still no detailed explanation for melanoma ulceration mechanism. Although thicker tumors are more commonly ulcerated, ulceration is a factor that predicts the disease outcome independently of melanoma thickness. It is our hypothesis that EGFR activates melanoma cell mobility. Melanoma cells with increased mobility move through tissue in diverse direction. Cells moving toward the epithelium weaken the intercellular bonds between the cells causing the loss of epithelium and subsequently ulceration.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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