Liječenje lupusnog nefritisa (CROSBI ID 227454)
Prilog u časopisu | pregledni rad (stručni)
Podaci o odgovornosti
Novak Srđan
hrvatski
Liječenje lupusnog nefritisa
Abstract Approximately 50% of patients with systemic lupus erythematosus will develop lupus nephritis. Signs of renal involvement such as proteinuria > or = 0.5 g/24 h especially with glomerular hematuria and/or cellular casts should be an indication for biopsy. Goals of immunosuppressive treatment in lupus nephritis is remission with avoidance of treatment-re- lated harms. Initial treatment for patients with class III (+/- V) and class IV (+/- V) LN are intravenous cyclophosphamide (total dose 3 g over 3 months) or mycophenolate mofetil (or mycophenolic acid) in target dose of 3 g/day for 6 months, always in combination with glucocorticoids, wihile in class V, mycophenolate mofetil in combination with glucocorticoids is recommended. In patients improving after initial treatment, mycophenolate mofetil at lower doses (2 g/day) or azatioprine (2 mg/kg/day), both in combination with low dose prednisone for at least 3 years are recommended. In resistant and relapse cases switch from cyclophosphamide to mycophenolate mofetil, or vice versa, or rituximab is recommended.
lupus nefritis; liječenje
nije evidentirano
engleski
treatment of lupus nephritis
nije evidentirano
luupusnephritis; treatment
nije evidentirano
Podaci o izdanju
7-8 (136)
2014.
215-219
objavljeno
0024-3477