engleski

Defects in ribosome biogenesis and diseases

Impairment of ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and consequently lead to improper execution of the genetic program and the development of specific diseases. p53 tumour supressor is activated upon ribosome biogenesis stress and has a critical role in pathogenesis of various diseases, including developmental abnormalities and cancer.

ribosome biogenesis; p53; cancer

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