engleski

Genetic manipulation of ribosome biogenesis in inflammation-driven liver cancer

The increased demand for proteins during processes that require growth, such as proliferation, differentiation, malignant transformation and tumor progression the cell must increase translational capacity by up-regulating ribosome biogenesis. To manipulate ribosome biogenesis in vivo, we analyzed impact of conditional inactivation of one RPS6 allele on the DEN/PB- induced HCC and the relative contribution of the impaired protein synthesis and p53 activation to this therapeutic effect.

ribosome biogenesis; cancer; inflammation

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