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Pregled bibliografske jedinice broj: 811987

Melanoma can control development of metastasis - Fact or myth?

Čabrijan, Leo; Batinac, Tanja; Lipozenčić, Jasna
Melanoma can control development of metastasis - Fact or myth? // Medical hypotheses, 89 (2016), 65-67 doi:10.1016/j.mehy.2016.02.009 (međunarodna recenzija, članak, znanstveni)

Melanoma can control development of metastasis - Fact or myth?

Čabrijan, Leo ; Batinac, Tanja ; Lipozenčić, Jasna

Medical hypotheses (0306-9877) 89 (2016); 65-67

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Melanoma ; metastases development

The malignant melanoma spreading process cannot explain occurrence of metastases several years following local surgical therapy of primary malignancy. But, this complex process of delayed metastases is still challenging and not completely understood. We hypotheses that melanoma metastases occur early in disease, probably at the same time with the occurrence of the primary melanoma. We suggest that dissemination of metastatic "seed cells" occur at an early stage of the disease together with the development of primary melanoma and cannot be detected by standard diagnostic methods. These cells are masked between healthy cells and have the potential to proceed in true metastasis following the activation triggered by signal from primary tumor or other source. Other possibility includes the existence of two different genes, one responsible for development of primary melanoma, and the other with a roll in development of metastases. We believe that future investigation should be directed toward better understanding of mechanisms involved in metastases development keeping in mind that melanoma behavior is irrational and defies logical thinking.

Izvorni jezik

Znanstvena područja
Kliničke medicinske znanosti


Medicinski fakultet, Rijeka

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus