Napredna pretraga

Pregled bibliografske jedinice broj: 811916

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection


Arapović, Maja; Brizić, Ilija; Popović, Branka; Jurković, Slaven; Jordan, S; Krmpotić, Astrid; Arapović, Jurica; Jonjić, Stipan
Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection // Frontiers in Immunology, 7 (2016), 133, 10 doi:10.3389/fimmu.2016.00133 (međunarodna recenzija, članak, znanstveni)


Naslov
Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection

Autori
Arapović, Maja ; Brizić, Ilija ; Popović, Branka ; Jurković, Slaven ; Jordan, S ; Krmpotić, Astrid ; Arapović, Jurica ; Jonjić, Stipan

Izvornik
Frontiers in Immunology (1664-3224) 7 (2016); 133, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ly49H ; NK cells ; bone-marrow chimera ; m157 ; mouse cytomegalovirus ; perforin ; proliferation

Sažetak
In addition to their role as effector cells in virus control, natural killer (NK) cells have an immunoregulatory function in shaping the antiviral T-cell response. This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine secretion upon mouse cytomegalovirus (MCMV) infection. Here, we confirmed that stronger activation and maturation of NK cells in perforin-deficient mice correlates with higher MCMV load. To further characterize the immunoregulatory potential of perforin, we compared the response of NK cells that express or do not express perforin using bone-marrow chimeras. Our results demonstrated that the enhanced proliferation and maturation of NK cells in MCMV-infected bone-marrow chimeras is an intrinsic property of perforin-deficient NK cells. Thus, in addition to confirming that NK- cell proliferation is virus load dependent, our data extend this notion demonstrating that perforin plays an intrinsic role as a feedback mechanism in the regulation of NK-cell proliferation during viral infections.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Arapović, Maja; Brizić, Ilija; Popović, Branka; Jurković, Slaven; Jordan, S; Krmpotić, Astrid; Arapović, Jurica; Jonjić, Stipan
Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection // Frontiers in Immunology, 7 (2016), 133, 10 doi:10.3389/fimmu.2016.00133 (međunarodna recenzija, članak, znanstveni)
Arapović, M., Brizić, I., Popović, B., Jurković, S., Jordan, S., Krmpotić, A., Arapović, J. & Jonjić, S. (2016) Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection. Frontiers in Immunology, 7, 133, 10 doi:10.3389/fimmu.2016.00133.
@article{article, year = {2016}, pages = {10}, DOI = {10.3389/fimmu.2016.00133}, chapter = {133}, keywords = {Ly49H, NK cells, bone-marrow chimera, m157, mouse cytomegalovirus, perforin, proliferation}, journal = {Frontiers in Immunology}, doi = {10.3389/fimmu.2016.00133}, volume = {7}, issn = {1664-3224}, title = {Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection}, keyword = {Ly49H, NK cells, bone-marrow chimera, m157, mouse cytomegalovirus, perforin, proliferation}, chapternumber = {133} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati