engleski

Importance of Publishing Papers Dealing with Temporomandibular Disorder and Masticatory Muscle Pain

The etiology of TMD is poorly understood, but it is recognized to be multifactorial.The involvement of neural mechanisms in etiopathogenesis of TMD is supported by the fact that unilateral inflammation of the masseter muscle in rats and muscle pain in humans is able to induce a bilateral and widespread mechanical allodynia and hyperalgesia. Since ion channels regulate neural excitability, at both peripheral and central level, they are proposed to be involved in nociception of deep craniofacial tissues. Accumulating results suggest importance of various ion channels like TRPV1, ATP receptor P2X, ASIC in orofacial pain conditions.

ion channels; temporomandibular disorders

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