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Pregled bibliografske jedinice broj: 811033

Isochromosome 17q in Chronic Lymphocytic Leukemia


Alhourani, Eyad; Rincic, Martina; Melo, Joana B; Carreira, Isabel M; Glaser, Anita; Pohle, Beate; Schlie, Cordula; Liehr, Thomas
Isochromosome 17q in Chronic Lymphocytic Leukemia // Leukemia research and treatment, 2015:489592 (2015) (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 811033 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Isochromosome 17q in Chronic Lymphocytic Leukemia

Autori
Alhourani, Eyad ; Rincic, Martina ; Melo, Joana B ; Carreira, Isabel M ; Glaser, Anita ; Pohle, Beate ; Schlie, Cordula ; Liehr, Thomas

Izvornik
Leukemia research and treatment (2090-3219) 2015:489592 (2015);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic lymphocytic leukemia (CLL); TP53 gene; isochromosome i(17q); interphase fluorescence in situ hybridization (iFISH); MLPA; aCGH

Sažetak
In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of TP53 gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence in situ hybridization (iFISH). Deletion of TP53 may but must not go together with the formation of an isochromosome i(17q) ; surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q) could be indicative for a new subgroup in CLL with more adverse prognosis. As a result, TP53 deletion was detected in 18 out of 150 (12%) here studied CLL cases. Six of those cases (~33%) had the TP53 deletion accompanied by an i(17q). Interestingly, the cases with i(17q) showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with TP53 deletion with and without i(17q) ; it may be suggested that the i(17q) presents an even more adverse prognostic marker than TP53 deletion alone.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Martina Rinčić (autor)


Citiraj ovu publikaciju:

Alhourani, Eyad; Rincic, Martina; Melo, Joana B; Carreira, Isabel M; Glaser, Anita; Pohle, Beate; Schlie, Cordula; Liehr, Thomas
Isochromosome 17q in Chronic Lymphocytic Leukemia // Leukemia research and treatment, 2015:489592 (2015) (međunarodna recenzija, članak, znanstveni)
Alhourani, E., Rincic, M., Melo, J., Carreira, I., Glaser, A., Pohle, B., Schlie, C. & Liehr, T. (2015) Isochromosome 17q in Chronic Lymphocytic Leukemia. Leukemia research and treatment, 2015:489592.
@article{article, year = {2015}, keywords = {chronic lymphocytic leukemia (CLL), TP53 gene, isochromosome i(17q), interphase fluorescence in situ hybridization (iFISH), MLPA, aCGH}, journal = {Leukemia research and treatment}, volume = {2015:489592}, issn = {2090-3219}, title = {Isochromosome 17q in Chronic Lymphocytic Leukemia}, keyword = {chronic lymphocytic leukemia (CLL), TP53 gene, isochromosome i(17q), interphase fluorescence in situ hybridization (iFISH), MLPA, aCGH} }
@article{article, year = {2015}, keywords = {chronic lymphocytic leukemia (CLL), TP53 gene, isochromosome i(17q), interphase fluorescence in situ hybridization (iFISH), MLPA, aCGH}, journal = {Leukemia research and treatment}, volume = {2015:489592}, issn = {2090-3219}, title = {Isochromosome 17q in Chronic Lymphocytic Leukemia}, keyword = {chronic lymphocytic leukemia (CLL), TP53 gene, isochromosome i(17q), interphase fluorescence in situ hybridization (iFISH), MLPA, aCGH} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI





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