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Pregled bibliografske jedinice broj: 811020

A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia


OTHMAN, MONEEB A.K.; GRYGALEWICZ, BEATA; PIENKOWSKA‑GRELA, BARBARA; RYGIER, JOLANTA; EJDUK, ANNA; RINCIC, MARTINA; MELO, JOANA B.; CARREIRA, ISABEL M.; MEYER, BRITTA; LIEHR, THOMAS
A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia // Oncology Letters, 11 (2016), 3; 2117-2122 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 811020 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia

Autori
OTHMAN, MONEEB A.K. ; GRYGALEWICZ, BEATA ; PIENKOWSKA‑GRELA, BARBARA ; RYGIER, JOLANTA ; EJDUK, ANNA ; RINCIC, MARTINA ; MELO, JOANA B. ; CARREIRA, ISABEL M. ; MEYER, BRITTA ; LIEHR, THOMAS

Izvornik
Oncology Letters (1792-1074) 11 (2016), 3; 2117-2122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immunoglobulin heavy locus gene rearrangement; cyclin-dependent kinase inhibitor 2A; B deletion; B-cell acute lymphoblastic leukemia; array-comparative genomic hybridization; molecular cytogenetics

Sažetak
Acquired copy number changes are common in acute leukemia. They are reported as recurrent amplifications or deletions (del), and may be indicative of involvement of oncogenes or tumor suppressor genes in acquired disease, as well as serving as potential biomarkers for prognosis or as targets for molecular therapy. The present study reported a gain of copy number of 14q13 to 14q32, leading to immunoglobulin heavy chain locus splitting in a young adult female. To the best of our knowledge, this rearrangement has not been previously reported in B-cell acute lymphoblastic leukemia (ALL). Low resolution banding cytogenetics performed at the time of diagnosis revealed a normal karyotype. However, retrospective application of fluorescence in situ hybridization (FISH) banding and locus-specific FISH probes, as well as multiplex ligation-dependent probe amplification and high resolution array-comparative genomic hybridization, revealed previously hidden aberrations. Overall, a karyotype of 46, XX, del(9) (p21.3 p21.3), derivative(14) (pter-> q32.33:: q32.33-> q13 ::q32.33-> qter) was determined. The patient was treated according to the Polish Adult Leukemia Group protocol and achieved complete remission. The results of the present study indicate that a favorable prognosis is associated with these aberrations when the aforementioned treatment is administered.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Martina Rinčić (autor)


Citiraj ovu publikaciju:

OTHMAN, MONEEB A.K.; GRYGALEWICZ, BEATA; PIENKOWSKA‑GRELA, BARBARA; RYGIER, JOLANTA; EJDUK, ANNA; RINCIC, MARTINA; MELO, JOANA B.; CARREIRA, ISABEL M.; MEYER, BRITTA; LIEHR, THOMAS
A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia // Oncology Letters, 11 (2016), 3; 2117-2122 (međunarodna recenzija, članak, znanstveni)
OTHMAN, M., GRYGALEWICZ, B., PIENKOWSKA‑GRELA, B., RYGIER, J., EJDUK, A., RINCIC, M., MELO, J., CARREIRA, I., MEYER, B. & LIEHR, T. (2016) A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia. Oncology Letters, 11 (3), 2117-2122.
@article{article, year = {2016}, pages = {2117-2122}, keywords = {immunoglobulin heavy locus gene rearrangement, cyclin-dependent kinase inhibitor 2A, B deletion, B-cell acute lymphoblastic leukemia, array-comparative genomic hybridization, molecular cytogenetics}, journal = {Oncology Letters}, volume = {11}, number = {3}, issn = {1792-1074}, title = {A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia}, keyword = {immunoglobulin heavy locus gene rearrangement, cyclin-dependent kinase inhibitor 2A, B deletion, B-cell acute lymphoblastic leukemia, array-comparative genomic hybridization, molecular cytogenetics} }
@article{article, year = {2016}, pages = {2117-2122}, keywords = {immunoglobulin heavy locus gene rearrangement, cyclin-dependent kinase inhibitor 2A, B deletion, B-cell acute lymphoblastic leukemia, array-comparative genomic hybridization, molecular cytogenetics}, journal = {Oncology Letters}, volume = {11}, number = {3}, issn = {1792-1074}, title = {A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia}, keyword = {immunoglobulin heavy locus gene rearrangement, cyclin-dependent kinase inhibitor 2A, B deletion, B-cell acute lymphoblastic leukemia, array-comparative genomic hybridization, molecular cytogenetics} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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