engleski

Therapeutic monitoring of immunosuppressive drugs: Where do we stand?

In the first half of the 20th century, attempts at transplantation of organs were unsuccessful because there were no clear ideas about the processes of immune response. With the advances in immunology, immunosuppressive drugs were developed. Initially, it was thought that successful immunosuppression can be achieved only by achieving complete immunodeficiency. Today we are entering an era in which the aim of a standard combination therapy will be no more to suppress the immune system, but to modulate it. Eff ective, safe and cost-eff ective therapy requires dosage individualization based on therapeutic drug monitoring.

cyclosporine; everolimus; immunosuppressive drugs; mycophenolic acid; sirolimus; tacrolimus; therapeutic drug monitoring

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