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Pregled bibliografske jedinice broj: 810253

Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event


Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Gdovinova Z, Švigelj V, Csiba L, Fekete K, Kõrv J; Demarin, Vida; Bašic- Kes, Vanja; Vilionskis A, Jatuzis D, Krespi Y, Shamalov N, Andonova S, Ahmed N, Wahlgren N;
Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event // Stroke, 46 (2015), 11; 3184-3189 doi:10.1161/STROKEAHA.115.010420 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 810253 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event

Autori
Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Gdovinova Z, Švigelj V, Csiba L, Fekete K, Kõrv J ; Demarin, Vida ; Bašic- Kes, Vanja ; Vilionskis A, Jatuzis D, Krespi Y, Shamalov N, Andonova S, Ahmed N, Wahlgren N ;

Izvornik
Stroke (0039-2499) 46 (2015), 11; 3184-3189

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acute stroke ; alteplase ; off-label use ; recurrence ; thrombolysis ; treatment outcome

Sažetak
BACKGROUND AND PURPOSE: According to the European license, alteplase can be given no sooner than 3 months after previous stroke. However, it is not known whether past history of stroke influences the effect of treatment. Our aim was to evaluate safety and functional outcome after intravenous thrombolysis administered in everyday practice to patients with previous stroke≤3 months compared with those with first-ever stroke. METHODS: We analyzed consecutive cases treated with alteplase between October 2003 and July 2014 contributed to the Safe Implementation of Thrombolysis for Stroke-Eastern Europe registry from 12 countries. Odds ratios were calculated using unadjusted and adjusted logistic regression. RESULTS: Of 13, 007 patients, 11, 221 (86%) had no history of stroke and 249 (2%) experienced previous stroke≤3 months before admission. Patients with previous stroke≤3 months had a higher proportion of hypertension and hyperlipidemia. There were no significant differences in outcome, including symptomatic intracerebral hemorrhage according to European Cooperative Acute Stroke Study (unadjusted odds ratio 1.27, 95% confidence interval: 0.74- 2.15), and being alive and independent at 3 months (odds ratio 0.81, 95% confidence interval: 0.61-1.09). CONCLUSIONS: Patients currently treated with alteplase, despite a history of previous stroke≤3 months, do not seem to achieve worse outcome than those with first- ever stroke. Although careful patient selection was probably of major importance, our findings provide reassurance that this group of patients may safely benefit from thrombolysis and should not be arbitrarily excluded as a whole. Further studies are needed to identify the shortest safe time lapse from the previous event to treatment with alteplase.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Hrvatska akademija znanosti i umjetnosti

Profili:

Avatar Url Vanja Bašić Kes (autor)

Avatar Url Vida Demarin (autor)

Citiraj ovu publikaciju

Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Gdovinova Z, Švigelj V, Csiba L, Fekete K, Kõrv J; Demarin, Vida; Bašic- Kes, Vanja; Vilionskis A, Jatuzis D, Krespi Y, Shamalov N, Andonova S, Ahmed N, Wahlgren N;
Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event // Stroke, 46 (2015), 11; 3184-3189 doi:10.1161/STROKEAHA.115.010420 (međunarodna recenzija, članak, znanstveni)
Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Gdovinova Z, Švigelj V, Csiba L, Fekete K, Kõrv J, Demarin, V., Bašic- Kes, V., Vilionskis A, Jatuzis D, Krespi Y, Shamalov N, Andonova S, Ahmed N, Wahlgren N & (2015) Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event. Stroke, 46 (11), 3184-3189 doi:10.1161/STROKEAHA.115.010420.
@article{article, year = {2015}, pages = {3184-3189}, DOI = {10.1161/STROKEAHA.115.010420}, keywords = {acute stroke, alteplase, off-label use, recurrence, thrombolysis, treatment outcome}, journal = {Stroke}, doi = {10.1161/STROKEAHA.115.010420}, volume = {46}, number = {11}, issn = {0039-2499}, title = {Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event}, keyword = {acute stroke, alteplase, off-label use, recurrence, thrombolysis, treatment outcome} }
@article{article, year = {2015}, pages = {3184-3189}, DOI = {10.1161/STROKEAHA.115.010420}, keywords = {acute stroke, alteplase, off-label use, recurrence, thrombolysis, treatment outcome}, journal = {Stroke}, doi = {10.1161/STROKEAHA.115.010420}, volume = {46}, number = {11}, issn = {0039-2499}, title = {Safe Implementation of Treatments in Stroke– East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event}, keyword = {acute stroke, alteplase, off-label use, recurrence, thrombolysis, treatment outcome} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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