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Pregled bibliografske jedinice broj: 810136

Monoaminergic Neuropathology in Alzheimer's disease


Šimić, Goran; Babić Leko, Mirjana; Wray, Selina; Harrington, Charles; Delalle, Ivana; Jovanov-Milošević, Nataša; Bažadona, Danira; Buée, Luc; de Silva, Rohan; Di Giovanni, Giuseppe et al.
Monoaminergic Neuropathology in Alzheimer's disease // Progress in neurobiology, 151 (2017), 4; 101-138 doi:10.1016/j.pneurobio.2016.04.001 (međunarodna recenzija, članak, znanstveni)


Naslov
Monoaminergic Neuropathology in Alzheimer's disease

Autori
Šimić, Goran ; Babić Leko, Mirjana ; Wray, Selina ; Harrington, Charles ; Delalle, Ivana ; Jovanov-Milošević, Nataša ; Bažadona, Danira ; Buée, Luc ; de Silva, Rohan ; Di Giovanni, Giuseppe ; Wischik, Claude ; Hof, Patrick R.

Izvornik
Progress in neurobiology (0301-0082) 151 (2017), 4; 101-138

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-hydroxytryptamine (serotonin) ; Alzheimer's disease ; amyloid beta (Aβ) protein ; blood-brain barrier ; cerebrospinal fluid ; epigenetics ; locus coeruleus ; metals ; monoamines ; neurofibrillary degeneration ; non-cognitive symptoms ; nucleus raphe dorsalis ; phosphorylation ; sleep-wake cycle ; tau protein

Sažetak
None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution patterns of the neuropathological changes at the cellular and regional levels, and their clinical correlates. One aspect of this problem lies in the complex genetic, epigenetic, and environmental landscape of AD: early-onset AD is often familial with autosomal dominant inheritance, while the vast majority of AD cases are late-onset, with the ε4 variant of the gene encoding apolipoprotein E (APOE) known to confer a 5-20 fold increased risk with partial penetrance. Mechanisms by which genetic variants and environmental factors influence the development of AD pathological changes, especially neurofibrillary degeneration, are not yet known. Here we review current knowledge of the involvement of the monoaminergic systems in AD. The changes in the serotonergic, noradrenergic, dopaminergic, histaminergic, and melatonergic systems in AD are briefly described. We also summarize the possibilities for monoamine-based treatment in AD. Besides neuropathologic AD criteria that include the noradrenergic locus coeruleus (LC), special emphasis is given to the serotonergic dorsal raphe nucleus (DRN). Both of these brainstem nuclei are among the first to be affected by tau protein abnormalities in the course of sporadic AD, causing behavioral and cognitive symptoms of variable severity. The possibility that most of the tangle-bearing neurons of the LC and DRN may release amyloid β as well as soluble monomeric or oligomeric tau protein trans-synaptically by their diffuse projections to the cerebral cortex emphasizes their selective vulnerability and warrants further investigations of the monoaminergic systems in AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-IP-2014-09-9730 - Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • CAB Abstracts
  • Current Biotechnology Abstracts
  • MEDLINE
  • Neurosciences Abstracts


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