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Pregled bibliografske jedinice broj: 809821

PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke


Bazina, Antonela; Sertić, Jadranka; Mišmaš, Antonija; Lovrić, Tena; Poljaković, Zdravka; Miličić, Davor.
PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke // Gene, 560 (2015), 2; 200-204 doi:10.1016/j.gene.2015.02.003. (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 809821 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke

Autori
Bazina, Antonela ; Sertić, Jadranka ; Mišmaš, Antonija ; Lovrić, Tena ; Poljaković, Zdravka ; Miličić, Davor.

Izvornik
Gene (0378-1119) 560 (2015), 2; 200-204

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ischemic stroke ; genes ; polymorphisms

Sažetak
AIM: Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-γ and IL-6 gene variants on IS onset. MATERIAL AND METHODS: A total of 301 subjects (144 males, 157 females) participated in the study, 114 patients with IS and 187 healthy controls. RESULTS: Statistically significant predictors of IS were male gender (OR 7.13, 95% CI 2.92-17.39, p<0.001), hypertension (OR 7.82. 95% CI 2.53-24.19, p<0.001), lowered HDL cholesterol (OR 8.20, 95% CI 2.41-27.94, p=0.001), elevated C-reactive protein (OR 5.26, 95% CI 1.92-14.41) and IL-6 -174 GC (OR 2.44 95% CI 1.01-5.91, p=0.0048) genotype. Males, compared to females, had 7 times higher odds for stroke. IL6 -174G/C genotype increased the odds for IS for 2.4 times. PPARγ was not statistically significantly associated with stroke. CONCLUSION: We can point to the IL-6 -174G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
108-1080134-0136 - Funkcijska genomika i proteomika rizičnih čimbenika ateroskleroze (Sertić, Jadranka, MZOS - )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdravka Poljaković (autor)

Avatar Url Jadranka Sertić (autor)

Citiraj ovu publikaciju

Bazina, Antonela; Sertić, Jadranka; Mišmaš, Antonija; Lovrić, Tena; Poljaković, Zdravka; Miličić, Davor.
PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke // Gene, 560 (2015), 2; 200-204 doi:10.1016/j.gene.2015.02.003. (međunarodna recenzija, članak, znanstveni)
Bazina, A., Sertić, J., Mišmaš, A., Lovrić, T., Poljaković, Z. & Miličić, D. (2015) PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke. Gene, 560 (2), 200-204 doi:10.1016/j.gene.2015.02.003..
@article{article, year = {2015}, pages = {200-204}, DOI = {10.1016/j.gene.2015.02.003.}, keywords = {Ischemic stroke, genes, polymorphisms}, journal = {Gene}, doi = {10.1016/j.gene.2015.02.003.}, volume = {560}, number = {2}, issn = {0378-1119}, title = {PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke}, keyword = {Ischemic stroke, genes, polymorphisms} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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