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Efficacy of tenofovir and efavirenz in combination with lamivudine or emtricitabine in antiretroviral-naive patients in Europe (CROSBI ID 226787)

Prilog u časopisu | ostalo

Swartz, J.E ; Vandekerckhove, L ; Ammerlaan, H ; de Vries, A.C ; Begovac, Josip ; Bierman, W.F ; Boucher, C.A ; van der Ende, M.E ; Grossman, Z ; Kaiser, R et al. Efficacy of tenofovir and efavirenz in combination with lamivudine or emtricitabine in antiretroviral-naive patients in Europe // Journal of antimicrobial chemotherapy, 70 (2015), 6; 1850-1857. doi: 10.1093/jac/dkv033

Podaci o odgovornosti

Swartz, J.E ; Vandekerckhove, L ; Ammerlaan, H ; de Vries, A.C ; Begovac, Josip ; Bierman, W.F ; Boucher, C.A ; van der Ende, M.E ; Grossman, Z ; Kaiser, R ; Levy, I ; Mudrikova, T ; Paredes, R ; Perez-Bercoff, D ; Pronk, M ; Richter, C ; Schmit, J.C ; Vercauteren, J ; Zazzi, M ; Židovec Lepej, Snježana ; European Society for translational Antiviral Research (ESAR)

engleski

Efficacy of tenofovir and efavirenz in combination with lamivudine or emtricitabine in antiretroviral-naive patients in Europe

BACKGROUND: The combination of tenofovir and efavirenz with either lamivudine or emtricitabine (TELE) has proved to be highly effective in clinical trials for first-line treatment of HIV-1 infection. However, limited data are available on its efficacy in routine clinical practice. METHODS: A multicentre cohort study was performed in therapy-naive patients initiating ART with TELE before July 2009. Efficacy was studied using ITT (missing or switch = failure) and on-treatment (OT) analyses. Genotypic susceptibility scores (GSSs) were determined using the Stanford HIVdb algorithm. RESULTS: Efficacy analysis of 1608 patients showed virological suppression to <50 copies/mL at 48 weeks in 91.5% (OT) and 70.6% (ITT). Almost a quarter of all patients (22.9%) had discontinued TELE at week 48, mainly due to CNS toxicity. Virological failure within 48 weeks was rarely observed (3.3%, n = 53). In multilevel, multivariate analysis, infection with subtype B (P = 0.011), baseline CD4 count <200 cells/mm³ (P < 0.001), GSS <3 (P = 0.002) and use of lamivudine (P < 0.001) were associated with a higher risk of virological failure. After exclusion of patients using co- formulated compounds, virological failure was still more often observed with lamivudine. Following virological failure, three-quarters of patients switched to a PI-based regimen with GSS <3. After 1 year of second-line therapy, viral load was suppressed to <50 copies/mL in 73.5% (OT). CONCLUSIONS: In clinical practice, treatment failure on TELE regimens is relatively frequent due to toxicity. Virological failure is rare and more often observed with lamivudine than with emtricitabine. Following virological failure on TELE, PI-based second-line therapy was often successful despite GSS <3.

HIV-1 ; co-formulation ; first-line antiretroviral therapy

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Podaci o izdanju

70 (6)

2015.

1850-1857

objavljeno

0305-7453

10.1093/jac/dkv033

Povezanost rada

nije evidentirano

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