Lipogenesis and lipid peroxidation in rat testes after long-term treatment with sucrose and tannic acid in drinking water (CROSBI ID 226763)
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Mašek, Tomislav ; Starčević, Kristina
engleski
Lipogenesis and lipid peroxidation in rat testes after long-term treatment with sucrose and tannic acid in drinking water
We studied the influence of long-term treatment with sucrose and tannic acid in drinking water on the fatty acid profile and lipid peroxidation in rat testes. Male Wistar rats were supplemented with sucrose (30% w/v) or with sucrose and tannic acid (sucrose 30% w/v, tannic acid 0.1% w/v) in drinking water. The treatment with sucrose elevated blood glucose levels in the plasma (P < 0.05), and decreased the testis weight (P < 0.05) and testis index (P < 0.05) of the rats. Sucrose treatment increased monounsaturated fatty acids (MUFA) and C22:6n3, and decreased n6 fatty acids in testis tissue. Lipid peroxidation was significantly increased after sucrose administration in plasma (P < 0.05) and testis tissue (P < 0.01). The addition of tannic acid led to the decrease in lipid peroxidation in the plasma (P < 0.05) and testis (P < 0.05) and a further increase in MUFA and decrease in n6 fatty acids. In conclusion, sucrose significantly altered the testis fatty acid profile with an increase in MUFA and C22:6n3, and a decrease in n6 fatty acids. Tannic acid attenuated oxidative stress and hyperglycemia, but it did not improve pathological changes in the fatty acid composition of the testis.
Fatty acids ; Lipid peroxidation ; Tannic acid ; Sucrose
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