Pregled bibliografske jedinice broj: 808355
In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer
In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer // Chemical communications, 52 (2016), 5120-5123 doi:10.1039/C6CC01583B (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 808355 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer
Autori
Huskić, Igor ; Christopherson, Jan-Constantin ; Užarević, Krunoslav ; Friščić, Tomislav
Izvornik
Chemical communications (1359-7345) 52
(2016);
5120-5123
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Vapour-induced reactions ; solid-state transformations ; in situ monitoring ; pharmaceutical materials ; polymorphism ; intermediates
Sažetak
We describe a simple setup for in situ continuous monitoring of vapour-induced transformations of organic solids using a benchtop powder X-ray diffractometer. Proof-of- principle application of this setup to model pharmaceutical cocrystals reveals complex reactivity, transformations of reaction intermediates within minutes, and a simple route to the rarely observed monoclinic form of the pharmaceutical cocrystal of carbamazepine and saccharin.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
FP7-NEWFELPRO-62
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Krunoslav Užarević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Arts & Humanities Citation Index (A&HCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
- Nature Index
