engleski

Standardization in laboratory medicine: Adoption of common reference intervals to the Croatian population

Considering the fact that the results of laboratory tests provide useful information about the state of health of patients, determination of reference value is considered an intrinsic part in the development of laboratory medi¬cine. There are still huge differences in the analytical methods used as well as in the asso¬ciated reference intervals which could consequently significantly affect the proper assessment of patient health. In a constant effort to increase the quality of patients’ care, there are numerous international initiatives for standardiza¬tion and/or harmonization of laboratory diagnostics in order to achieve maximum comparability of laboratory test results and improve patient safety. Through the standardization and harmonization proce¬sses of analytical methods the ability to create unique reference intervals is achieved. Such reference intervals could be applied globally in all laboratories using methods traceable to the same reference measuring system and analysing the biological samples from the populations with similar socio-demographic and ethnic characteristics. In this review we outlined the results of the harmonization processes in Croatia in the field of population based reference intervals for clinically relevant blood and serum con¬stituents which are in accordance with ongoing activity for worldwide standardization and harmonization based on traceability in laboratory medicine.

Calibration traceability; Applicability of reference intervals; Harmonization and standardisation; External quality assessment; International Federation of Clinical Chemistry enzyme reference methods; Amino­transferase “common” reference intervals; Creatinine enzymatic method

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