TPL2-NPM-p53 pathway monitors nucleolar stress (CROSBI ID 226072)
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Eliopoulos, Aristides G. ; Volarević, Siniša
engleski
TPL2-NPM-p53 pathway monitors nucleolar stress
Tumor Progression Locus 2 (TPL2) is widely recognized as a cytoplasmic mitogen-activated protein 3 kinase with a prominent role in the regulation of inflammatory and oncogenic signal transduction. TPL2 may also operate in the nucleus as a physical and functional partner of nucleophosmin (NPM/B23), a major nucleolar phosphoprotein with diverse cellular activities linked to malignancy. NPM is an endogenous inhibitor of HDM2:p53 interaction and knockdown of TPL2 has a role to reduce binding of NPM to HDM2, with concomitant defects in p53 accumulation following genotoxic or ribosomal stress.
TPL2; nucleolus; nucleophosmin; p53
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