engleski

What is the role of the pre-germinative zone?

In the adult mouse lens epithelium the proliferation index varies with latitude. Near the lens equator, a 300 μm-wide germinative zone (GZ) shows the highest rate of cell proliferation. Anterior to the GZ is a 400 μm- wide swath of cells called the pregerminative zone (PGZ). The rate of cell division in the PGZ is approximately 10-fold lower than in the GZ. In this study, we used a stochastic model to explore the specific contribution of the PGZ to lens growth.

epithelium ; proliferation ; growth model

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