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Pregled bibliografske jedinice broj: 806203

Resveratrol and Alzheimer’s Disease: Mechanistic Insights


Ahmed, Touqeer; Javed, Sehrish; Javed, Sana; Tariq, Ameema; Šamec, Dunja; Tejada, Silvia; Nabavi, Seyed Fazel; Braidy, Nady; Nabavi, Seyed Mohammad
Resveratrol and Alzheimer’s Disease: Mechanistic Insights // Molecular neurobiology, 54 (2017), 4; 2622-2635 doi:10.1007/s12035-016-9839-9 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Resveratrol and Alzheimer’s Disease: Mechanistic Insights

Autori
Ahmed, Touqeer ; Javed, Sehrish ; Javed, Sana ; Tariq, Ameema ; Šamec, Dunja ; Tejada, Silvia ; Nabavi, Seyed Fazel ; Braidy, Nady ; Nabavi, Seyed Mohammad

Izvornik
Molecular neurobiology (0893-7648) 54 (2017), 4; 2622-2635

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Alzheimer’s disease ; resveratrol ; amyloid ; neurodegeneration ; neuroinflammation

Sažetak
Alzheimer’s disease is the leading cause of dementia in the elderly, and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of Alzheimer’s disease include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of Alzheimer’s disease, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3, 5, 4′-trihydroxy-trans-stilbene), have been investigated in several in vitro and in vivo models of Alzheimer’s disease. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of Alzheimer’s disease. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol will also be addressed

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Dunja Šamec, (312892)

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • AGRICOLA


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