engleski

Resveratrol and Alzheimer’s Disease: Mechanistic Insights

Alzheimer’s disease is the leading cause of dementia in the elderly, and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of Alzheimer’s disease include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of Alzheimer’s disease, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3, 5, 4′-trihydroxy-trans-stilbene), have been investigated in several in vitro and in vivo models of Alzheimer’s disease. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of Alzheimer’s disease. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol will also be addressed

Alzheimer’s disease ; resveratrol ; amyloid ; neurodegeneration ; neuroinflammation

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