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Intracellular life of Francisella and Legionella within amoebae cells

Free-living amoebae are present in the nature, feeding mainly with bacteria, fungi, and algae. Some microorganisms have evolved different mechanisms to resist the digestion by amoebae and they are called “amoeba-resistant microorganisms”. Some of the important human bacterial pathogens belong to this category including Cryptococcus neoformans, Chlamydophila pneumoniae, Mycobacterium avium, Listeria monocytogenes, Pseudomonas aeruginosa, Legionella spp., and Francisella tularensis. Francisella and Legionella are gram negative facultative intracellular bacteria. Although the diseases they cause are completely different, they share some of the unique features in intracellular lifestyle within amoeba cells.

Amoeba; Francisella; Legionella

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