engleski

Effects of propolis components (naringenin, quercetin, chrysin and caffeic acid) on serum and liver lipids of mice on a high fat diet

Naringenin, quercetin, chrysin and caffeic acid are potent natural antioxidants and active compounds of propolis. Lipids are a large group of biological compounds. They are insoluble in water and therefore transferred in blood stream as lipoprotein 254 complexes. Lipoproteins are complexes of lipids and apolipoproteins. They are classified according to size, density, and lipid - apolipoprotein ratio: chylomicrons, very low density lipoprotein (VLDL), low density lipoproteins (LDL), intermediate density lipoproteins (IDL) and high density lipoproteins (HDL). Large amounts of LDL are not absorbed in the liver and consumed by macrophages, so they accumulate in the blood stream causing oxidative stress and many pathological conditions. In this study we examined the effects of active compounds of propolis on the composition of serum and liver lipids in mice on high-fat diet. The antioxidants from propolis, namely: naringenin, quercetin, chrysin and caffeic acid were given orally to mice at dose of 50 mg/kg/bw every 48 h, for 30 days. At the end of the treatment serum total triglyceride, cholesterol, HDL, LDL, serum enzymes and metabolites (AST, ALT, ALP i LDH), liver enzymes (MDH and CAT) and MDA product of lipid peroxidation were measured. In our experiment we demonstrated that quercetin, chrysin and caffeic acid have negative effects because they increase the “bad” and decrease “good” cholesterol in serum, and show hepatotoxic effects. On the other hand, no negative effect of naringenin were observed.

HDL- cholesterol ; LDL- cholesterol ; oxidative stress ; lipid peroxidation ; propolis

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