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Pregled bibliografske jedinice broj: 798082

The role of host genetic factors in respiratory tract infectious diseases : systematic review, meta-analyses and field synopsis


Patarčić, Inga; Gelemanović, Andrea; Kirin , Mirna; Kolčić, Ivana; Theodoratou, Evropei; ...; Rudan, Igor; Campbell, Harry; Polašek, Ozren
The role of host genetic factors in respiratory tract infectious diseases : systematic review, meta-analyses and field synopsis // Scientific Reports, 5 (2015), 16119-1 doi:1038/srep16119 (međunarodna recenzija, članak, znanstveni)


Naslov
The role of host genetic factors in respiratory tract infectious diseases : systematic review, meta-analyses and field synopsis

Autori
Patarčić, Inga ; Gelemanović, Andrea ; Kirin , Mirna ; Kolčić, Ivana ; Theodoratou, Evropei ; ... ; Rudan, Igor ; Campbell, Harry ; Polašek, Ozren

Izvornik
Scientific Reports (2045-2322) 5 (2015); 16119-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Genetics; infection; host

Sažetak
Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24, 823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874 ; 1.66 [1.29-2.14]). We also detected an association of TLR2 gene with tuberculosis (rs5743708 ; 3.19 [2.03-5.02]). Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611 ; OR = 0.79 [0.72-0.88]). The IL4-TLR2-CCL2 axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-IP-2013-11-8875 - Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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