Napredna pretraga

Pregled bibliografske jedinice broj: 797348

High VEGF serum values are associated with locoregional spread of gastroenteropancreatic neuroendocrine tumors (GEP-NETs)


Cigrovski Berković, Maja; Čačev, Tamara; Catela Ivković, Tina; Marout, Jasminka; Ulamec, Monika; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
High VEGF serum values are associated with locoregional spread of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) // Molecular and cellular endocrinology, 425 (2016), 61-68 doi:10.1016/j.mce.2016.01.013 (međunarodna recenzija, članak, znanstveni)


Naslov
High VEGF serum values are associated with locoregional spread of gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Autori
Cigrovski Berković, Maja ; Čačev, Tamara ; Catela Ivković, Tina ; Marout, Jasminka ; Ulamec, Monika ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Izvornik
Molecular and cellular endocrinology (0303-7207) 425 (2016); 61-68

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gastroenteropancreatic neuroendocrine tumors; gastrointestinal neuroendocrine tumors; pancreatic neuroendocrine tumors; VEGF; polymorphism; metastasis

Sažetak
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly vascularized neoplasms, capable of synthethisizing VEGF-A, a key mediator of angiogenesis. In pancreatic neuroendocrine tumors (pNETs) VEGF expression is higher in benign and low-grade tumors and associated with good prognosis (neuroendocrine paradox) while the VEGF role in gastrointestinal NETs (GI-NETs) is still unclear. In this study, we examined the VEGF-1154A/G polymorphism in 145 GEP-NET patients and 150 controls. Next, we measured VEGF serum levels and VEGF tumor protein expression, comparing it with Ki67 and tumor grade. Patients’ VEGF serum levels were compared with VEGF -1145A/G genotypes and metastatic status as well as with chromogranin A (CgA) and 5-hydroxyindolacetic acid (5-HIAA) in case of GI-NET patients. In this study GEP-NET patients had elevated VEGF serum values when compared to healthy controls (p=0.0013). VEGF-1145G allele correlated with higher VEGF serum levels (p=0.002). Patients with metastatic tumors had higher VEGF serum values when compared to patients without metastases (p=0.033), and highest levels were observed in case of lymph node metastases (p=0.008). VEGF-1145G allele was more frequent in non-functional GI-NET patients than in healthy controls (p=0.041). CgA was superior to VEGF in tumor detection, while VEGF was superior to 5-HIAA. A correlation was observed between VEGF immunohistochemical staining and Ki-67 (p=0.028). Tumours with weaker VEGF protein expression were more aggressive than tumours with stronger VEGF expression, confirming a „neuroendocrine paradox“ in GI-NETs. Our results suggest the role of VEGF in GI-NETs locoregional spread.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Sanja Kapitanović, )
134-1342428-0491 - Neuroendokrini tumori probavnog sustava i gušterače (Maja Cigrovski Berković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati