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Pregled bibliografske jedinice broj: 796438

The 2H+/2e− free radical scavenging mechanisms of uric acid: thermodynamics of N-H bond cleavage


Amić, Ana; Marković, Zoran; Dimitrić Marković, Jasmina; Lučić, Bono; Stepanić, Višnja; Amić, Dragan
The 2H+/2e− free radical scavenging mechanisms of uric acid: thermodynamics of N-H bond cleavage // Computational and Theoretical Chemistry, 1077 (2016), 2-10 doi:10.1016/j.comptc.2015.09.003 (međunarodna recenzija, članak, znanstveni)


Naslov
The 2H+/2e− free radical scavenging mechanisms of uric acid: thermodynamics of N-H bond cleavage

Autori
Amić, Ana ; Marković, Zoran ; Dimitrić Marković, Jasmina ; Lučić, Bono ; Stepanić, Višnja ; Amić, Dragan

Izvornik
Computational and Theoretical Chemistry (2210-271X) 1077 (2016); 2-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Uric acid; Free radical scavenging; Double SPLET; Double HAT; DFT; SMD

Sažetak
Double (2H+/2e-) free radical scavenging mechanisms of the most abundant endogenous plasma antioxidant uric acid were theoretically studied using DFT method M05-2X/6-311++G(d, p) coupled with SMD solvation model. Calculations were performed for double, two sequential 1H+/1e- hydrogen atom transfer (HAT), double electron transfer followed by proton transfer (ET–PT) and double sequential proton loss electron transfer (SPLET) mechanisms in water as a solvent. It was found that inactivation of the first free radical by uric acid (the first 1H+/1e- mechanism) occurs at its 3-N site and inactivation of another one (the second 1H+ /1e- mechanism) occurs at 7-N site of uric acid 3-N radical. The final product of all studied 2H+ /2e- pathways is uric acid quinonoid diimine. Obtained results point to the SPLET mechanism as the favorable free radical scavenging mechanism by uric acid. Taking into account electronic properties of scavenged free radicals, double HAT mechanism is found to be competitive to double SPLET mechanism. Second mechanisms are less energy demanding than the first ones indicating 2H+/2e- processes as plausible. On the basis of exergonicity of the calculated reaction free energies, the reactivity of uric acid toward free radicals was predicted to decrease as follows: HO and Cl3COO > alkoxyl, peroxyl >> superoxide radical.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
S.I.: Antioxidants vs. Oxidative Stres : Insights from Computation.



POVEZANOST RADA


Ustanove
Fakultet agrobiotehničkih znanosti Osijek,
Institut "Ruđer Bošković", Zagreb,
Sveučilište u Osijeku - Odjel za biologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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