engleski

Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice

The therapeutic effects of cocoa polyphenols on acute carbon tetrachloride (CCl4) -intoxicated mice were investigated. After determination polyphenols profile in the cocoa extract (CE), CE at a dose of 34.5 mg/kg and epicatechin (EC) at a dose of 2.24 mg/kg were intraperitoneally (i.p.) administered to BALB/cN mice following CCl4-treatment. CE and EC post-treatments suppressed hepatotoxicity and inflammation, ameliorated serum markers of liver injury, returned blood lactate and glucose levels to normal, stimulated synthesis and storage of liver glycogen, and modulated glucose metabolism imbalance induced by CCl4. Cocoa polyphenols also exhibited early stage antifibrotic and anticarcinogenic effects. They affected beneficially mitochondrial functionality acting on dysfunction in mitochondrial respiration caused by CCl4 and antioxidants regulation at subcellular levels.

Cocoa polyphenols; Epicatechin; Liver damage; Antioxidants; Inflammation; Oxidative stress

This work has been supported by the University of Rijeka under the project number 13.11.1.2.02.