1, 4-Dihydropyridine Derivatives : Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress1, 4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress (CROSBI ID 223973)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Velena, Astrida ; Žarković, Neven ; Gall Trošelj, Koraljka ; Bisenieks, Egils ; Krauze, Aivars ; Poikans, Janis ; Duburs, Gunurs
engleski
1, 4-Dihydropyridine Derivatives : Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress1, 4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress
Many 1, 4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA). Several commercially available calcium antagonist, 1, 4-DHP drugs, their metabolites, and calcium agonists were shown to express AOA. Synthesis, hydrogen donor properties, AOA, and methods and approaches used to reveal biological activities of various groups of 1, 4-DHPs are presented. Examples of DHPs antioxidant activities and protective effects of DHPs against OS induced damage in low density lipoproteins (LDL), mitochondria, microsomes, isolated cells, and cell cultures are highlighted. Comparison of the AOA of different DHPs and other antioxidants is also given. According to the data presented, the DHPs might be considered as bellwether among synthetic compounds targeting OS and potential pharmacological model compounds targeting oxidative stress important for medicinal chemistry.
1 ; 4-Dihydropyridines ; oxidative stress ; aging ; disease prevention
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Podaci o izdanju
2016
2016.
1892412
35
objavljeno
1942-0900
1942-0994
10.1155/2016/1892412
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti