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Pregled bibliografske jedinice broj: 791981

Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia


Perković, Sanja; Ugrina, Ivo; Labar, Boris; Nemet, Damir; Batinić, Josip; Zadro, Renata; Ries, Sunčica; Gjadrov-Kuvedžić, Koraljka; Davidović, Sanja; Batinić, Drago
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia // Leukemia & lymphoma, 56 (2015), 8; 2281-2288 doi:10.3109/10428194.2014.990012 (međunarodna recenzija, članak, znanstveni)


Naslov
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia

Autori
Perković, Sanja ; Ugrina, Ivo ; Labar, Boris ; Nemet, Damir ; Batinić, Josip ; Zadro, Renata ; Ries, Sunčica ; Gjadrov-Kuvedžić, Koraljka ; Davidović, Sanja ; Batinić, Drago

Izvornik
Leukemia & lymphoma (1042-8194) 56 (2015), 8; 2281-2288

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute myeloid leukemia ; PI3K/Akt and MAPK signaling pathways ; P-glycoprotein

Sažetak
Acute myeloid leukemia (AML) is a malignant hematopoietic disease with poor clinical course and outcome. There is a constant need for new prognostic factors that could facilitate patient risk stratification. The aim of our research was to determine the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) pathways in leukemic cells, their relation to P-glycoprotein (P-gp) expression/activity and their prognostic significance in adult de novo AML. A total of 118 patients with AML were enrolled in the study. In a multivariate Cox regression analysis we found that P-gp activity and Akt phosphorylation were independent poor prognostic factors of overall survival (OS). In contrast, phosphorylated extracellular signal- regulated kinase 1/2 (ERK1/2) represented a favorable prognostic factor of OS and relapse- free survival (RFS). A negative correlation between P-gp activity and p38 phosphorylation level was found, implying a possible role of this MAPK pathway in P-gp regulation. In addition, we found correlation between Akt and p38 phosphorylation levels, indicative of co- activation of two signaling cascades in AML.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
GENOS d.o.o.,
Sveučilište Libertas

Citiraj ovu publikaciju

Perković, Sanja; Ugrina, Ivo; Labar, Boris; Nemet, Damir; Batinić, Josip; Zadro, Renata; Ries, Sunčica; Gjadrov-Kuvedžić, Koraljka; Davidović, Sanja; Batinić, Drago
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia // Leukemia & lymphoma, 56 (2015), 8; 2281-2288 doi:10.3109/10428194.2014.990012 (međunarodna recenzija, članak, znanstveni)
Perković, S., Ugrina, I., Labar, B., Nemet, D., Batinić, J., Zadro, R., Ries, S., Gjadrov-Kuvedžić, K., Davidović, S. & Batinić, D. (2015) Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia. Leukemia & lymphoma, 56 (8), 2281-2288 doi:10.3109/10428194.2014.990012.
@article{article, year = {2015}, pages = {2281-2288}, DOI = {10.3109/10428194.2014.990012}, keywords = {Acute myeloid leukemia, PI3K/Akt and MAPK signaling pathways, P-glycoprotein}, journal = {Leukemia and lymphoma}, doi = {10.3109/10428194.2014.990012}, volume = {56}, number = {8}, issn = {1042-8194}, title = {Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia}, keyword = {Acute myeloid leukemia, PI3K/Akt and MAPK signaling pathways, P-glycoprotein} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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