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Pregled bibliografske jedinice broj: 791981

Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia


Perković, Sanja; Ugrina, Ivo; Labar, Boris; Nemet, Damir; Batinić, Josip; Zadro, Renata; Ries, Sunčica; Gjadrov-Kuvedžić, Koraljka; Davidović, Sanja; Batinić, Drago
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia // Leukemia & lymphoma, 56 (2015), 8; 2281-2288 doi:10.3109/10428194.2014.990012 (međunarodna recenzija, članak, znanstveni)


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Naslov
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia

Autori
Perković, Sanja ; Ugrina, Ivo ; Labar, Boris ; Nemet, Damir ; Batinić, Josip ; Zadro, Renata ; Ries, Sunčica ; Gjadrov-Kuvedžić, Koraljka ; Davidović, Sanja ; Batinić, Drago

Izvornik
Leukemia & lymphoma (1042-8194) 56 (2015), 8; 2281-2288

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute myeloid leukemia ; PI3K/Akt and MAPK signaling pathways ; P-glycoprotein

Sažetak
Acute myeloid leukemia (AML) is a malignant hematopoietic disease with poor clinical course and outcome. There is a constant need for new prognostic factors that could facilitate patient risk stratification. The aim of our research was to determine the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) pathways in leukemic cells, their relation to P-glycoprotein (P-gp) expression/activity and their prognostic significance in adult de novo AML. A total of 118 patients with AML were enrolled in the study. In a multivariate Cox regression analysis we found that P-gp activity and Akt phosphorylation were independent poor prognostic factors of overall survival (OS). In contrast, phosphorylated extracellular signal- regulated kinase 1/2 (ERK1/2) represented a favorable prognostic factor of OS and relapse- free survival (RFS). A negative correlation between P-gp activity and p38 phosphorylation level was found, implying a possible role of this MAPK pathway in P-gp regulation. In addition, we found correlation between Akt and p38 phosphorylation levels, indicative of co- activation of two signaling cascades in AML.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
GENOS d.o.o.,
Sveučilište Libertas

Citiraj ovu publikaciju

Perković, Sanja; Ugrina, Ivo; Labar, Boris; Nemet, Damir; Batinić, Josip; Zadro, Renata; Ries, Sunčica; Gjadrov-Kuvedžić, Koraljka; Davidović, Sanja; Batinić, Drago
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia // Leukemia & lymphoma, 56 (2015), 8; 2281-2288 doi:10.3109/10428194.2014.990012 (međunarodna recenzija, članak, znanstveni)
Perković, S., Ugrina, I., Labar, B., Nemet, D., Batinić, J., Zadro, R., Ries, S., Gjadrov-Kuvedžić, K., Davidović, S. & Batinić, D. (2015) Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia. Leukemia & lymphoma, 56 (8), 2281-2288 doi:10.3109/10428194.2014.990012.
@article{article, year = {2015}, pages = {2281-2288}, DOI = {10.3109/10428194.2014.990012}, keywords = {Acute myeloid leukemia, PI3K/Akt and MAPK signaling pathways, P-glycoprotein}, journal = {Leukemia and lymphoma}, doi = {10.3109/10428194.2014.990012}, volume = {56}, number = {8}, issn = {1042-8194}, title = {Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia}, keyword = {Acute myeloid leukemia, PI3K/Akt and MAPK signaling pathways, P-glycoprotein} }
@article{article, year = {2015}, pages = {2281-2288}, DOI = {10.3109/10428194.2014.990012}, keywords = {Acute myeloid leukemia, PI3K/Akt and MAPK signaling pathways, P-glycoprotein}, journal = {Leukemia and lymphoma}, doi = {10.3109/10428194.2014.990012}, volume = {56}, number = {8}, issn = {1042-8194}, title = {Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen- activated protein kinase phosphorylation in acute myeloid leukemia}, keyword = {Acute myeloid leukemia, PI3K/Akt and MAPK signaling pathways, P-glycoprotein} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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